One Food is a unifying approach to conceptually frame and practically guide the transition of food systems to ensure food and nutrition security for all through safer, healthier and climate-resilient food production, trade and consumption. It binds together the complex intersections between food systems, climate dynamics and livelihoods into a holistic perspective. The One Food project launch workshop at Dinokeng in Gauteng (South Africa), held from 31 October to 2 November 2022, elevated the natural science elements of this approach and reinforced the need for including social and human science aspects into it. This Advisory Report (Road Map) shows how to incorporate social science issues into the One Food project, with specific emphasis on food systems hazard identification and control. Making social and human aspects of food systems explicit rather than implicit in the One Food project is thus the overarching purpose and message of this report.