The Fourth Industrial Revolution is having, and will continue to have, a significant and multi-faceted impact on the gambling industry in South Africa, raising a wide scope of new challenges and demands for regulators. This report looks at the impacts including a scoping of the legal, policy, and regulatory environments, a scan of the technological dynamics of the 4IR and how these impact on the gambling sector, and in-depth interviews with a wide range of stakeholders. From a synthesis of these core knowledge resources, key issues have been identified for regulators.